Arun Krishna

Rob Dillard

Lung Cancers Today

AstraZeneca has announced that the US Food and Drug Administration has approved Tagrisso (osimertinib) with the addition of chemotherapy in adult patients with locally advanced or metastatic epidermal growth factor receptor-mutated (EGFRm) non-small cell lung cancer (NSCLC). The decision is based on the phase 3 FLAURA2 trial results published in the New England Journal of Medicine, which demonstrated extended median progression-free survival (PFS) by nearly 9 months versus standard of care.
Recently, AstraZeneca also announced positive high-level results from the phase 3 LAURA trial, a global study for Tagrisso patients with unresectable, stage 3 EGFRm NSCLC after chemoradiotherapy (CRT) compared with placebo after CRT. As of now, the LAURA results show:
<ul>
<li>Tagrisso following chemoradiation demonstrated a statistically significant and highly clinically meaningful improvement in PFS.</li>
<li>These results reinforce Tagrisso as a key player in delaying disease progression, offering potential benefits for patients without worsening their condition.</li>
</ul>
Lung Cancers Today spoke with Arun Krishna, VP and head of the US Lung Cancer Franchise at AstraZeneca, to discuss the importance of the new Tagrisso data and recent approval, as well as elaborate on the positive milestones for the company’s advancing lung franchise and the impact these data will have on patients and oncologists.

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Arun Krishna on the FLAURA2 Trial Results: Tagrisso Effectively Combats NSCLC

Arun Krishna, of AstraZeneca, talks about the phase 3 FLAURA2 trial, which assessed Tagrisso in patients with NSCLC.