The study participants include those who have had at least one first-degree relative diagnosed with lung cancer. Sophie Poznanski, PhD, shares insights from her ASCO 2025 presentation on the multifunctional antibody modality. The study compared results from North America with global results by high-income and low- or middle-income countries. Cheryl Czerlanis, MD, shares insights from the session on lung cancer screening that she chaired at ASCO 2025. Palliative care researchers discuss differences in lung cancer treatment disparities across Hispanic patient subgroups. Helena Yu, MD, discusses research updates from REZILIENT1 that were presented at ASCO 2025. Jennifer Carlisle, MD, discusses amivantamab, and the multidimensional impact of toxicity management at ASCO 2025. Coral Olazagasti, MD, shares why the ASCO Annual Meeting is a critical time to bring the field together. Dr. Sanjay Juneja and Dr. Eric Singhi join a special episode of DDx for a candid conversation on a real patient case. Dr. Singhi unpacks the thoracic oncology data and highlights coming up at this year's ASCO Annual Meeting. Stephen V. Liu, MD, shares what he sees as the key upcoming highlights in thoracic oncology at the ASCO Annual Meeting. Eric Singhi, MD, discusses the recent FDA approval and explains the associated new biomarker testing considerations. Mara Antonoff, MD, explains the nuances of determining if a patient with oligometastatic disease is a candidate for surgery. Ravi Rajaram, MD, MSc, discusses Medicaid expansion, timely access to care, regionalization effects, and remaining questions. Michael R. Gieske, MD, discusses why Lung Cancer Action Week is a key time to promote screening and shares recent milestones. Dr. Liu discusses his experience as co-chair of the Texas Lung Cancer Conference and shares key highlights. Dr. Spira shares key data from cohort C of CHRYSALIS-2 that was presented at the European Lung Cancer Congress 2025. Mara Antonoff, MD, discusses key advances and addresses common misconceptions about operating in oligometastatic disease. Dr. Weiss noted the results in both feasibility and safety, particularly via injection, which had limited complications. Dr. Mara Antonoff discusses why it's critical to offer information and updates on surgery for oligometastatic lung cancer.