The study is evaluating if hydrogen peroxide in exhaled breath condensate can be used as a biomarker for lung cancer. Study investigators suggested there may be a “promising therapeutic strategy for advancing NK cell-based immunotherapy." Researchers synthesized circular RNA encoding NY-ESO-1, which is expressed in a proportion of patients with NSCLC. Dr. Spira shares key data from cohort C of CHRYSALIS-2 that was presented at the European Lung Cancer Congress 2025. Dr. Weiss noted the results in both feasibility and safety, particularly via injection, which had limited complications. The study explored the effect of immune checkpoint inhibition on real-world patients with NSCLC versus trial patients. The phase 1 LuCa-MERIT-1 trial is evaluating BNT116, an unmodified RNA-based lipoplex cancer vaccine, with cemiplimab. John V. Heymach, MD, PhD, of the MD Anderson Cancer Center, presented results from the trial at AACR 2025. Kathryn C. Arbour, MD, of the Memorial Sloan Kettering Cancer Center, presented results from the study at AACR 2025. Dr. Liu discusses key data and updates in EGFR-positive NSCLC from the European Lung Cancer Congress. Margarita Majem, MD, PhD, presented the results as a late-breaking abstract during the European Lung Cancer Congress 2025. Nicolas Girard, MD, PhD, discusses data on subcutaneous amivantamab in patients with advanced NSCLC. The session covered everything from new actionable immune checkpoints to vaccines, cellular therapies, and bispecifics. Dr. Ladanyi reflects on genetic hotspot mutations that have not been previously well characterized in lung adenocarcinoma. Martin Reck, MD, PhD, reflects on key updates in stage III NSCLC from the European Lung Cancer Congress 2025. Suresh Senan, MRCP, FRCR, PhD, presented the data at the European Lung Cancer Congress 2025 in Paris, France. Martin Reck, MD, PhD, presented the final analysis at the European Lung Cancer Congress 2025. Subcutaneous pembrolizumab may be “a viable treatment option" in indications where pembrolizumab is approved. Andrea Riccardo Filippi, MD, presented survival data from the final PACIFIC-R data extraction with over 5 years of follow-up. Suresh S. Ramalingam, MD, FACP, FASCO, presented the data during a proffered paper session at ELCC 2025.